Recently, a comment is made by a poster that “This whole new PVT Prednisone Lot thing is a Joke!” expressing his/her frustration with the use of the tablets or the practice of PVT. Such comments reflecting the erratic and unpredictable behavior of PVT, previously called apparatus calibration, are not new and have been reported extensively in the literature.
However, a more serious question and concern should be that if the performance of an apparatus cannot be verified appropriately, as recommended and required by the USP, then how reliable would the testing of the pharmaceutical products be using such an apparatus?
This seems to confirm literature reports that there are problems in using the apparatuses, because of poor hydrodynamics within dissolution vessels. Therefore, caution should be observed in assessing the quality of products using such apparatuses.
