Sink condition – an invalid and unscientific concept and requirement!

Drug dissolution testers, in particular most commonly recommended ones (paddle and basket), are based on closed system/environment i.e. without a drain, therefore, it is not possible to have or create a sink condition. Authorities and pharmacopeias require it while “experts” create it. How? Magic!

In addition, one does not even require a sink condition for in vitro drug dissolution testing. 900 ml of water with or without a small amount of solubilizer sufficient to (freely) dissolve the expected amount of drug present in the product – is all one needs. For further details please follow the link here to simplify your life and avoid wasting time and resources (link).

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