Selecting a Dissolution Apparatus – Some Practical Considerations

A commonly asked question is how one should select a dissolution apparatus. It may be of interest to know that, such a question is often asked when a dissolution analyst gets frustrated with the unexpected or unanticipated dissolution behavior of a test product. Such a question is seldom asked at the beginning of the project as it is always understood or assumed that one will most likely use a paddle apparatus. Furthermore, the analyst will try some variations of rpm (50, 75 or 100) or medium (different buffers and pHs). If this does not work, then perhaps the basket apparatus will be tried with similar variations in rpms and buffers. In the end, the analyst usually settles with a test which will provide the anticipated/expected characteristics of the test product. .(please click here for complete post)

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