The science of drug dissolution testing: Testers or apparatuses, experimental conditions and interpretation of results – A systematic approach for learning

This article summarizes the principles of drug dissolution testing with an emphasis on the underlying scientific assumptions that are often not clearly described, or understood. It should be noted that the technique itself is extremely simple to use, however, current practices of selecting experimental conditions and the interpretation of dissolution results are seriously misunderstood, and require attention. To address these deficiencies, analysts should seek essential training in the areas of relevant physiology and pharmacokinetics. In the absence of such required training and knowledge of the subjects, it is highly unlikely that an analytical laboratory can generate relevant and accurate dissolution data, thus will fail in meeting the products development and evaluation objectives. Links to some articles on the subjects are provided which may help the analysts in improving their overall skills in these areas. Please click here for complete article

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